Coagulation activity in liver disease

Coagulation in Liver Disease

Coagulation defects in liver disease.

By the introduction of the one-stage prothrombin test in 1935 Quick first devised a measure of the coagulation defect in liver disease (Quick, Stanley-Brown, and Bancroft, 1935). He subsequently (1938) pointed out that failure to absorb vitamin K in obstructive jaundice or failure to synthesize prothrombin in disease caused by parenchymatous liver-cell damage was the cause of the prolonged one-...

Tests of coagulation in liver disease.

The complex coagulation defect secondary to chronic liver disease is considered responsible for the bleeding problems that often are associated with the disease. Accordingly, clinicians order laboratory tests to assess the risk of bleeding and rely on these results to make decisions about the management of the associated coagulation disturbances. Recent data, however, indicate that the abnormal...

Coagulation abnormalities in patients with chronic liver disease in Pakistan.

OBJECTIVE To determine the coagulation abnormalities and relationship between abnormal clotting tests and the risk of gastrointestinal bleeding (GI) among chronic liver disease (CLD) patients admitted at a tertiary care hospital in Pakistan. METHODS Adult CLD patients admitted at Liaquat University Hospital Jamshoro, during Nov 2004-Oct 2005, were included in the study. The patients blood wer...

Thromboelastographic Evaluation of Coagulation in Patients With Liver Disease

BACKGROUND The aims of this study were to investigate the parameters of thromboelastography (TEG) for evaluating coagulopathy and to reveal an association with disease severity and/or transfusion requirement in patients with chronic liver disease (CLD) in a clinical laboratory setting. METHODS We enrolled two groups of adult patients with cirrhotic (N=123) and non-cirrhotic liver disease (N=5...